ea0077oc1.3 | Reproductive and Neuroendocrinology | SFEBES2021
Mistry Anisha
, Funge Gregory
, Sebastian Sonia
, Aziz Qadeer
, Solomou Antonia
, Vignola Maria Lillina
, Thong Lim Chung
, Herincs Maria
, Caimari Francisca
, Gaston-Massuet Carles
, Tinker Andrew
, Korbonits Marta
Introduction: Patients with a germline loss-of-function mutation in AIP are predisposed to young-onset GH excess resulting in gigantism or acromegaly. Acromegaly leads to disease-specific cardiomyopathy with biventricular hypertrophy and diastolic dysfunction progressing to fulminant cardiac failure if left untreated, therefore it is vital to have a tractable animal model to investigate the diseaseFindings: Our AipFlox/Flox;<...